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The San Diego Union-Tribune

San Diego startup DTx Pharma raises $100M for platform to treat rare diseases

DTx Pharma, a 15-employee San Diego biotechnology company pursuing a platform for creating RNA-based therapies to treat genetic drivers of rare diseases, said Monday that it has raised $100 million in Series B round of financing. The early stage company, which previously raised $10.6 million in a Series A round in January 2020, is pursuing

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Fierce Biotech

Merck inks $1.9B Pandion takeover to square up against Amgen, Lilly and Roche

Merck has struck a $1.9 billion deal to buy Pandion. The takeover will give Merck control of a pipeline of immune modulators led by a rival to IL-2 drugs in development at Amgen, Eli Lilly and Roche. Pandion went public last year, pulling in $135 million to fund the development of a pipeline led by

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FierceBiotech

Childhood cancer-focused Day One banks $130M for pan-RAF inhibitor

It’s been a busy year for Day One Biopharmaceuticals. Just nine months after debuting with $60 million to tackle childhood cancers, the company is topping up its coffers with a $130 million series B financing. The funds will bankroll development and launch plans for its lead program, a pan-RAF inhibitor it’s developing for children with

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STAT

Sanofi, aiming to speed MS treatment, to acquire Principia Biopharma for $3.68 billion

Sanofi said Monday that it is acquiring Principia Biopharma for $3.68 billion, giving the French drug giant full control over the multiple sclerosis treatment the companies share. The deal values Principia at $100 per share, a 10% premium over the company’s closing price Friday, but represents a 35% premium to the price of Principia’s stock

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Endpoints News

The man who led Gilead’s autoimmune pivot heads to Boston

Now Sundy is moving on. On Tuesday, he left Gilead to become the CMO of Pandion Therapeutics, a Boston biotech building “bifunctional” antibodies for inflammatory diseases. It was the technology that attracted him, Sundy said. The company was developing ways to not treat immune conditions across the entire body. Instead, they were building tethers to link immune-modulating

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STAT

Startup Spotlight: Aiming to speed precision cancer therapies to children

Day One Biopharmaceuticals — named for the conversations clinicians have with parents when they first tell them their child has cancer and how they hope to treat it — announced on Thursday its first financing and its first drug candidate. Backed by $60 million from Canaan, Access Biotechnology, and Atlas Venture, the 25-person startup has

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FierceBiotech

Day One debuts with $60M to change cancer care—starting with children

“There have been over 200 products approved by the FDA for adult cancers even in the last 20 years, but in the last 30, there have been less than 10 new drugs approved by the FDA specifically for children with cancer,” said Julie Grant, a general partner at Canaan Partners, who’s been working on a

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The Philadelphia Inquirer

Penn gene therapy pioneer Jim Wilson’s Passage Bio plans IPO

Philadelphia-based Passage Bio plans to raise as much as $125 million selling stock shares to the public through an initial public offering (IPO), the Philadelphia-based firm told the Securities and Exchange Commission in a public filing Monday. Passage Bio, based on gene therapy technology developed by University of Pennsylvania biotech pioneer James Wilson, says it

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FierceBiotech

Rare disease biotech Passage Bio nabs Deerfield veteran as CEO

Passage Bio is losing its interim chief executive and co-founder Stephen Squinto, Ph.D., as it brings in a venture capitalist veteran to the helm. The biotech will now be run by Bruce Goldsmith, who comes from Deerfield Management where he was a venture partner responsible for early-stage investments and also served as interim CEO at

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FierceBiotech

Quickfire megarounds tee Passage Bio up for gene therapy trials

Passage Bio has raised its second megaround of 2019. Months after breaking cover with a $115.5 million series A, the James Wilson-founded gene therapy startup has reeled in another $110 million to take several assets into the clinic while hustling other programs through preclinical studies.

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