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When Disc Medicine closed a $62.5 million raise led by Bain Capital earlier this year, the biotech’s CEO John Quisel pointed to the stream of clinical readouts in blood disorders it is expecting as the impetus. Now, it’s outlining the first of those data — with an open-label Phase II trial providing what it calls

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Upstream Bio has raised another $200 million to go through Phase II studies and prepare for late-stage trials of an ex-Astellas monoclonal antibody in anticipation of competition with AstraZeneca and Amgen’s asthma drug Tezspire.

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Day One Biopharmaceuticals will offer up more than 11.5 million shares to nab $150 million in gross proceeds after the biotech last month started a rolling submission for its pediatric brain cancer drug, which had a fresh data drop at last weekend’s ASCO.

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Acelyrin started trading on the Nasdaq Friday morning in one of the largest biotech initial public offerings in recent memory, with $540 million in gross proceeds and potentially $621 million if underwriters exercise their 30-day option to buy more shares.

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Drug licensor and developer Acelyrin revealed more of its IPO plans Monday morning, mapping out what could be one of the biggest biotech IPOs in the past few years if it raises $370 million by pricing at the high end of its proposed range. The California biotech aims to sell 20.6 million shares of common

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Hemab Therapeutics, led by Alnylam vet Benny Sorensen and chaired by John Maraganore, has raised $135 million from a new crop of investors as it begins pushing its blood disorder programs into the clinic. Hemab’s Series B was led by Access Biotechnology, followed by Deep Track Capital, Avoro Capital, Invus, Rock Springs Capital and Danish

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A leader in the protein degradation space, Yale’s Craig Crews, is back with another biotech, Halda Therapeutics. On Tuesday, the startup announced $76 million in funding to take forward a new technology out of Crews’ lab, called RIPTACs, or Regulated Induced Proximity TArgeting Chimeras. The 26-employee startup emerged from hid decades-long work on heterobifunctional molecules,

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Day One Biopharmaceuticals said Sunday that a targeted therapy shrank tumors by at least 50% in a majority of children with the most common form of pediatric brain cancer, setting up a potential approval in a rare disease long overlooked by drugmakers. The new data expand on earlier results released last year from 22 patients.

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Acelyrin said it acquired privately held ValenzaBio in an all-stock transaction but didn’t disclose further financial details of the acquisition. Acelyrin, which disclosed a $300 million venture financing in September led by Access Biotechnology, previously struck a deal with biotech Affibody AB to secure global rights to develop and commercialize a compound, izokibep, except in

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UK-based biotech Verona Pharma said Tuesday morning that its drug, ensifentrine, passed its second late-stage trial for the common lung disease COPD. In August, Verona reported the drug succeeded in the first of its two Phase III trials. Now, Verona will package together the new trial data in its approval filing to the FDA, which

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Nimbus Therapeutics’ midphase psoriasis data have persuaded Takeda that the biotech’s TYK2 inhibitor will be big. How big? $4 billion upfront and more again on the back end. Late last month, Nimbus presented top-line findings from a phase 2b clinical trial of NDI-034858, using the update to repeat its claim that the rival to Bristol

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In February, Endpoints News reported that Turenne had signed on to head a stealth mode Atlas Venture-backed biotech EoCys. After a name change in March, EoCys has evolved into Matchpoint Therapeutics, which is coming out of stealth with a $70 million Series A and a focus on making covalent drugs, or drugs that bind irreversibly.

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DICE Therapeutics is now moving forward on the next stage of clinical development for its IL-17 candidate, on the heels of touting a Phase I win. And investors are responding in kind. DICE reported topline data Tuesday from a Phase I trial enrolling 104 patients — a mix of healthy volunteers and psoriasis patients —

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Drugmaker Acelyrin Inc. has raised $300 million in new venture capital to run late-stage clinical trials of a drug that could treat certain forms of arthritis and other conditions and compete with top-selling medications. New investor Access Biotechnology led this financing for Acelyrin, which has secured more than $550 million in total venture financing. Acelyrin

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The computational chemistry biotech, co-founded in 2009 by VC Bruce Booth, announced its most recent financing round Monday worth $125 million — Nimbus’ fifth big financing in the last seven years. The round includes two new investors: Bain Capital Life Sciences and SV Health Investors. Other previous investors tagged along, including Access Biotechnology, Atlas Venture,

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UK-based Verona Pharma’s COPD drug, ensifentrine, has succeeded in its Phase III trial, paving the way for a possible FDA approval. In Verona’s Phase III ENHANCE-2 study, roughly 800 patients with moderate to severe COPD received ensifentrine or placebo through a nebulizer twice a day for 24 weeks. At 12 hours post-treatment on week 12,

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Anyone reading Biogen’s press release on the flat failure of dexpramipexole in treating ALS couldn’t overlook the note of finality then R&D chief Doug Williams used to mark its grave 10 years ago. The drug failed the primary endpoint. Follow-up analysis left no doubt about the flop. Williams recalls the readout in ALS as “a

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Day One Biopharmaceuticals reported Sunday that an experimental molecule shrank tumors by at least 50% in a majority of children with the most common form of childhood brain cancer, offering an early but rare glimmer of progress in a disease that has seen little over the last three decades. In the Phase 2 trial, 22

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The last time Samantha Truex was CEO of a biotech, she did something rare: She admitted defeat. Quench Bio was wrapping up after a “successful failure” and doing so with money in the bank to hand some capital back to investors. Now, Truex is back at the helm of Upstream Bio, a new inflammatory disease

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Amid a renaissance in the field of radiopharmaceuticals, a growing chorus of biopharma players is rushing the stage to capitalize on tech breakthroughs. Biotech blue-chippers RA Capital and Atlas Venture, sensing an opportunity, are now setting up their own startup to challenge the big boys. Curie Therapeutics uncloaked from stealth Wednesday with $75 million in

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Recludix Pharma, a San Diego biotech launched by a founding team of Blueprint Medicines vets, pulled in a $60 million Series A on Monday, promising investors a path to the holy grail STAT3 mutation through what’s called the SH2 domain. Taking over as chief executive is Nancy Whiting, arriving after a 15-year run at Seagen

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Nimbus Therapeutics has raised $105 million to put its allosteric TYK2 inhibitor through a clutch of phase 2 clinical trials. A syndicate of investors led by BVF Partners has come together to help Nimbus find out if its prospect lives up to that promise. Equipped with cash from new and existing investors including RA Capital

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Not two months after launching out of RA Capital’s incubator, Eliem Therapeutics is returning to the firm — and others — to raise another heap of cash. And this time, an IPO could potentially be in the works. Eliem has put together a $60 million Series B round co-led by RA Capital as it seeks

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Pediatric cancer biotech Day One Pharmaceuticals is headed for Nasdaq, in a move that comes less than three months after their work on a brain cancer treatment led to a nine-figure crossover round backed by some blue-chip investors. The South San Francisco-based company is penciling in $100 million as their initial IPO target, though the

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DTx Pharma, a 15-employee San Diego biotechnology company pursuing a platform for creating RNA-based therapies to treat genetic drivers of rare diseases, said Monday that it has raised $100 million in Series B round of financing. The early stage company, which previously raised $10.6 million in a Series A round in January 2020, is pursuing

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Merck has struck a $1.9 billion deal to buy Pandion. The takeover will give Merck control of a pipeline of immune modulators led by a rival to IL-2 drugs in development at Amgen, Eli Lilly and Roche. Pandion went public last year, pulling in $135 million to fund the development of a pipeline led by

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It’s been a busy year for Day One Biopharmaceuticals. Just nine months after debuting with $60 million to tackle childhood cancers, the company is topping up its coffers with a $130 million series B financing. The funds will bankroll development and launch plans for its lead program, a pan-RAF inhibitor it’s developing for children with

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Roughly nine months after emerging from stealth, Day One Biopharmaceuticals returned to the venture capital well and came away with a nine-figure prize. And with the hefty crossover round, it raises the big question of whether they’re prepping an S-1 to enter a hot biotech IPO market. Day One raised $130 million in a Series

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Sanofi said Monday that it is acquiring Principia Biopharma for $3.68 billion, giving the French drug giant full control over the multiple sclerosis treatment the companies share. The deal values Principia at $100 per share, a 10% premium over the company’s closing price Friday, but represents a 35% premium to the price of Principia’s stock

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Sanofi CEO Paul Hudson has a home for a chunk of that Regeneron money sitting in the bank. The pharma exec is shelling out $100 a share to take out Principia $PRNB — helmed by Martin Babler — and the MS drug that Hudson has been talking up for months as a breakthrough in the

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Now Sundy is moving on. On Tuesday, he left Gilead to become the CMO of Pandion Therapeutics, a Boston biotech building “bifunctional” antibodies for inflammatory diseases. It was the technology that attracted him, Sundy said. The company was developing ways to not treat immune conditions across the entire body. Instead, they were building tethers to link immune-modulating

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Day One Biopharmaceuticals — named for the conversations clinicians have with parents when they first tell them their child has cancer and how they hope to treat it — announced on Thursday its first financing and its first drug candidate. Backed by $60 million from Canaan, Access Biotechnology, and Atlas Venture, the 25-person startup has

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“There have been over 200 products approved by the FDA for adult cancers even in the last 20 years, but in the last 30, there have been less than 10 new drugs approved by the FDA specifically for children with cancer,” said Julie Grant, a general partner at Canaan Partners, who’s been working on a

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The Series B was led by Access Biotechnology, Boxer Capital, RA Capital and OrbiMed and included the participation of Polaris Partners, Versant Ventures, Roche Venture Fund, SR One, JDRF T1D Fund and BioInnovation Capital. The Boston-based startup raised $58 million in January 2018.

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Access Biotechnology and Boxer Capital led the $80 million round, joining new investors RA Capital and OrbiMed. And all of Pandion’s backers returned for the series B, including Polaris Partners, Versant Ventures, Roche Venture Fund, SR 1, JDRF T1D Fund and BioInnovation Capital.

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Philadelphia-based Passage Bio plans to raise as much as $125 million selling stock shares to the public through an initial public offering (IPO), the Philadelphia-based firm told the Securities and Exchange Commission in a public filing Monday. Passage Bio, based on gene therapy technology developed by University of Pennsylvania biotech pioneer James Wilson, says it

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Days ago when Deerfield partner Bruce Goldsmith jumped to helm Passage Bio, he cited a few reasons why it’s an “extremely exciting time” to be joining the gene therapy player: IND filings for three lead programs, a data-rich 2021 and an expanding pipeline of experimental drugs for rare, monogenic CNS diseases.

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Passage Bio is losing its interim chief executive and co-founder Stephen Squinto, Ph.D., as it brings in a venture capitalist veteran to the helm. The biotech will now be run by Bruce Goldsmith, who comes from Deerfield Management where he was a venture partner responsible for early-stage investments and also served as interim CEO at

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Brian MacDonald’s original foray into treating iron dysregulation by injecting hepcidin, a small peptide hormone key for iron homeostasis, didn’t quite get off the ground. This time, the former GSK executive is taking a fresh approach — by regulating hepcidin expression within the body.

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Passage Bio has raised its second megaround of 2019. Months after breaking cover with a $115.5 million series A, the James Wilson-founded gene therapy startup has reeled in another $110 million to take several assets into the clinic while hustling other programs through preclinical studies.

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The gene therapy biotech that James Wilson helped found to take some rare disease programs out of Penn all the way to an approval has scored $110 million in its latest financing.

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Texas VC Bios Partners has found a new early-stage play to love out of San Diego, leading a $28 million Series A to help Trefoil Therapeutics make the leap to the clinic.

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Trefoil Therapeutics announced it raised $28 million in an oversubscribed Series A financing. The company is developing novel engineered fibroblast growth factor-1 proteins (eFGF-1) as a regenerative pharmacologic therapy to treat serious corneal endothelial diseases and epithelial disorders.

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Right now, the only way to prevent blindness in patients with a group of genetic eye disorders called corneal dystrophies is with cornea transplant surgery. But Trefoil Therapeutics is looking to change that: It’s raised $28 million to push its regenerative treatment toward the clinic.

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Trefoil Therapeutics, a San Diego, CA-based private biotechnology company, raised $28m in Series A financing.

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Trefoil Therapeutics has raised $28 million in Series A financing, which will be used to support its phase 2a proof-of-concept study in corneal endothelial dystrophy, the company announced in a press release.

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San Diego biotech Trefoil Therapeutics recently brought in a $28 million series A round for work on vision diseases.

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Trefoil Therapeutics, which is developing treatments for diseases that affect the cornea, the outermost layer of the eye, has raised $28 million to move its lead drug candidate into human testing.

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Access Industries, a privately held industrial group, announced today the appointment of Dr. Liam Ratcliffe to head Access Biotechnology, a newly formed strategic investment arm specializing in therapeutic platforms and products.

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